Tuesday, April 30, 2013

7 Ways to Cut Your Diabetes Risk

Defend yourself against prediabetes and diabetes type 2 by sticking to these lifestyle habits, like lifting weights and getting a good night's sleep.

Cut Your Diabetes Risk

Upping your lean muscle mass could lower your insulin resistance and drop your odds of developing prediabetes, according to a new study in The Journal of Clinical Endocrinology & Metabolism. Researchers found that for every 10 percent increase in muscle mass, people's prediabetes risk fell by 12 percent. Build three days of resistance training into your weekly fitness plan, says Sheri Colberg-Ochs, Ph.D., a professor of exercise science at Old Dominion University. And aim for at least two and a half hours a week of glucose-burning cardio activity such as running, cycling, or swimming.

The pros and cons of cardio versus weight lifting: Which is better for you?

Cut Your Diabetes Risk

Long-term sleep deprivation may amp up the body's insulin resistance, especially in people genetically predisposed to diabetes. A preliminary University of Chicago study found that those who regularly snoozed fewer than six hours a night were at the highest risk. Try to get at least seven hours of shut-eye each evening.

10 Sleep Myths Busted

Cut Your Diabetes Risk

The rough stuff isn't just good for digestion?it also curbs post-meal sugar spikes by slowing down the flow of glucose into the bloodstream. So when you crave something sweet, opt for fiber-rich fruit such as raspberries or pears. And consider adding brown rice to your diet: Eating two or more servings a week lowers diabetes risk by 11 percent, says an Archives of Internal Medicine study.

Win The Fight Against Diabetes With Food

Cut Your Diabetes Risk

Chronic stress is a risk factor for many major diseases, including diabetes. "When your body senses stress, it releases hormones that increase blood sugar," says Colberg-Ochs. That rush is beneficial in a pinch but dangerous long-term. Regularly practicing deep breathing or meditation, listening to calming music, or getting massages can quell stress hormones and help lower overall blood sugar, she says. 31 Relaxation Techniques to Relieve Stress in Less Than 10 Minutes http://www.womenshealthmag.com/life/relax-instantly?cm_mmc=ABCNews-_-Top%205-_-7%20Ways%20To%20Cut%20Diabetes%20Risk-_-Destress%2031%20Ways%20To%20Relax

Cut Your Diabetes Risk

The omega-3 fatty acids found in foods like oily fish (wild salmon, sardines) can help improve insulin sensitivity. Nosh on at least one serving of such seafood a week.

The Supplement That Will Keep You Young

Cut Your Diabetes Risk

The "sunshine vitamin" may be a key factor in the fight against diabetes. A review published in The Journal of Clinical Endocrinology & Metabolism found that people with high vitamin-D levels were less likely to develop type 2. Swallow 1,000 to 2,000 IU a day through dairy foods, fatty fish, or supplements.

Benefits of Vitamin D

Source: http://abcnews.go.com/Health/Wellness/ways-cut-diabetes-risk/story?id=19053187

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Monday, April 29, 2013

How earthquakes in Chile have permanently deformed Earth

Earthquakes can permanently crack the Earth, an investigation of quakes that have rocked Chile over the past million years suggests.

Although earthquakes can wreak havoc on the planet's surface, more than a century of research has suggested the Earth actually mostly rebounds after quakes, with blocks of the world's crust elastically springing back, over the course of months to decades, to the way they initially were. Such rebounding was first seen after investigations of the devastating 1906 San Francisco temblor thathelped lead to the destruction of more than 80 percent of the city. The rebound is well-documented nowadays by satellite-based GPS systems that monitor Earth's movements.

However, structural geologist Richard Allmendinger of Cornell University and his colleagues now find major earthquakes of magnitude 7 or greater apparently caused the crust in northern Chile to crack permanently. [The 10 Biggest Earthquakes in History]

"My graduate students and I originally went to northern Chile to study other features," Allmendinger said. "While we were there, our Chilean colleague, Professor Gabriel Gonz?lez of the Universidad Cat?lica del Norte, took us to a region where these cracks were particularly well-exposed."

"I still remember feeling blown away ? never seen anything like them in my 40 years as a geologist ? and also perplexed," Allmendinger told OurAmazingPlanet. "What were these features and how did they form? Scientists hate leaving things like this unexplained, so it kept bouncing around in my mind."

Atacama exposed

In northern Chile, "the driest place on Earth, we have a virtually unique record of great earthquakes going back a million years," Allmendinger said. Whereas most analyses of ancient earthquakes only probe cycles of two to four quakes, "our record of upper plate cracking spans thousands of earthquake cycles," he noted.

The record of the vast number of earthquakes captured in northern Chilean rocks allowed the researchers to examine their average behavior over a much longer period of time, which makes it easier to pick out any patterns. They discovered that a small but significant 1 to 10 percent of the deformation of the Earth caused by 2,000 to 9,000 major quakes over the past 800,000 to 1 million years was permanent, involving cracks millimeters to meters large in the crust of the Atacama Desert. The crust may behave less elastically than previously thought.

"It is only in a place like the Atacama Desert that these cracks can be observed ? in all other places, surface processes erase them within days or weeks of their formation, but in the Atacama, they are preserved for millions of years," Allmendinger said. "We have every reason to believe that our results would be applicable to other areas, but is simply not preserved for study the way that it is in the Atacama Desert," he added.

Model rethink

This work "calls into question the details of models that geophysicists who study the earthquake cycle use," Allmendinger said. "Their models generally assume that all of the upper-plate deformation related to the earthquake cycle is elastic ? recoverable, like an elastic band ? and not permanent. If some of the deformation is permanent, then the models will have to be rethought and more complicated material behaviors used.

The area the researchers studied, the Iquique Gap, "is one of the few places along western South America that has not had a great earthquake in the last 100 years and thus has a high probability of a major earthquake in the next couple of decades," Allmendinger added. "We may get to test out predictions about earthquakes if the next great earthquake there happens in the next couple of decades."

The scientists detailed their findings online April 28 in the journal Nature Geoscience.

Follow OurAmazingPlanet?@OAPlanet, Facebook?and Google+. Original article at LiveScience's OurAmazingPlanet.

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/earthquakes-chile-permanently-deformed-earth-170116659.html

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Sniffing out schizophrenia

Apr. 29, 2013 ? A debilitating mental illness, schizophrenia can be difficult to diagnose. Because physiological evidence confirming the disease can only be gathered from the brain during an autopsy, mental health professionals have had to rely on a battery of psychological evaluations to diagnose their patients.

Now, Dr. Noam Shomron and Prof. Ruth Navon of Tel Aviv University's Sackler Faculty of Medicine, together with PhD student Eyal Mor from Dr. Shomron's lab and Prof. Akira Sawa of Johns Hopkins Hospital in Baltimore, Maryland, have discovered a method for physical diagnosis -- by collecting tissue from the nose through a simple biopsy. Surprisingly, collecting and sequencing neurons from the nose may lead to "more sure-fire" diagnostic capabilities than ever before, Dr. Shomron says.

This finding, which was reported in the journal Neurobiology of Disease, could not only lead to a more accurate diagnosis, it may also permit the crucial, early detection of the disease, giving rise to vastly improved treatment overall.

From the nose to diagnosis

Until now, biomarkers for schizophrenia had only been found in the neuron cells of the brain, which can't be collected before death. By that point it's obviously too late to do the patient any good, says Dr. Shomron. Instead, psychiatrists depend on psychological evaluations for diagnosis, including interviews with the patient and reports by family and friends.

For a solution to this diagnostic dilemma, the researchers turned to the olfactory system, which includes neurons located on the upper part of the inner nose. Researchers at Johns Hopkins University collected samples of olfactory neurons from patients diagnosed with schizophrenia and a control group of non-affected individuals, then sent them to Dr. Shomron's TAU lab.

Dr. Shomron and his fellow researchers applied a high-throughput technology to these samples, studying the microRNA of the olfactory neurons. Within these molecules, which help to regulate our genetic code, they were able to identify a microRNA which is highly elevated in those with schizophrenia, compared to individuals who do not have the disease.

"We were able to narrow down the microRNA to a differentially expressed set, and from there down to a specific microRNA which is elevated in individuals with the disease compared to healthy individuals," explains Dr. Shomron. Further research revealed that this particular microRNA controls genes associated with the generation of neurons.

In practice, material for biopsy could be collected through a quick and easy outpatient procedure, using a local anesthetic, says Dr. Shomron. And with microRNA profiling results ready in a matter of hours, this method could evolve into a relatively simple and accurate test to diagnose a very complicated illness.

Early detection, early intervention

Though there is much more to investigate, Dr. Shomron has high hopes for this diagnostic method. It's important to determine whether this alteration in microRNA expression begins before schizophrenic symptoms begin to exhibit themselves, or only after the disease fully develops, he says. If this change comes near the beginning of the timeline, it could be invaluable for early diagnostics. This would mean early intervention, better treatment, and possibly even the postponement of symptoms.

If, for example, a person has a family history of schizophrenia, this test could reveal whether they too suffer from the disease. And while such advanced warning doesn't mean a cure is on the horizon, it will help both patient and doctor identify and prepare for the challenges ahead.

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The above story is reprinted from materials provided by American Friends of Tel Aviv University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Eyal Mor, Shin-Ichi Kano, Carlo Colantuoni, Akira Sawa, Ruth Navon, Noam Shomron. MicroRNA-382 expression is elevated in the olfactory neuroepithelium of schizophrenia patients. Neurobiology of Disease, 2013; 55: 1 DOI: 10.1016/j.nbd.2013.03.011

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/zHXUhnxaa7s/130429130548.htm

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Google releases Glass kernel GPL source, lets developers have at it

While our own Tim Stevens is currently adapting to life through Google Glass, developers are going beyond scratching the surface to fiddle with what's inside. Hot on the heels of Jay Freeman rooting Glass, devs will be pleased to know Google's throwing 'em a bone to by publicly releasing the kernel source. Interestingly, Karthik's Geek Center spotted info within the file that points to Glass potentially being equipped for NFC support. If you're up for tinkering, you'll find the temporary location of the tar.zx file itself at the source link.

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Via: Karthik's Geek Center

Source: Google

Source: http://www.engadget.com/2013/04/27/google-releases-glass-kernel-gpl-source/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Sunday, April 28, 2013

Police say 4 people stabbed at Albuquerque church

ALBUQUERQUE, N.M. (AP) ? Police say a 24-year-old man stabbed four people at a Catholic church in Albuquerque as a Sunday mass was nearing its end.

Police spokesman Robert Gibbs says Lawrence Capener jumped over several pews at St. Jude Thaddeus Catholic Church around noon Sunday and walked up to the choir area where he began his attack.

The injuries to the four church-goers weren't life-threatening. All four were being treated at hospitals.

An off-duty police officer and others at the church subdued Capener and held him down until police arrived.

Some of those who were stabbed were members of the choir.

Gibbs says Capener is now being interviewed by police and is expected to face felony charges.

It's not yet known whether Capener has an attorney.

Gibbs says investigators don't yet know the motive for the stabbings, whether Capener had ties to the victims or whether he regularly attended the church.

The stabbings occurred as the choir had just begun its closing hymns.

Archbishop of Santa Fe Michael Sheehan released a statement saying he was saddened by the attack.

"I pray for all who have been harmed, their families, the parishioners and that nothing like this will ever happen again," Sheehan said.

The church didn't immediately return calls seeking comment on Sunday afternoon.

Source: http://news.yahoo.com/police-4-people-stabbed-albuquerque-church-224409447.html

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Old standards greet fans on Jazz Fest's 2nd day

(AP) ? At 101 years old, New Orleans jazz trumpeter Lionel Ferbos opened one of 12 stages on the second day of the New Orleans Jazz and Heritage Festival. Billy Joel brought the crowds and ended Day 2.

Couples danced and some sang along to old jazz standards such as "Back Home In Indiana" and "I Can't Give You Anything but Love" on Saturday.

Ferbos is believed to be the oldest actively working musician in the city. He performs regularly at the Palm Court Jazz Club in the French Quarter.

"He epitomizes New Orleans," said New Orleans resident Medora Monigold, a Jazz Fest veteran and fan of Ferbos. "In a day where the elders are not respected, he reminds us that wisdom and talent can exist at any age."

Monigold enjoyed a plate of seafood casserole and fried green tomatoes as she tapped her foot to the music.

Maryruth Senechal, of Hartford, Conn., said Ferbos was excellent. She said she catches his shows often at the Palm Court but prefers his performances at Jazz Fest.

"Here, I can dance and second-line. I love the old traditional brass band jazz," she said.

Senechal and her husband, Jean-Guy, have attended Jazz Fest 14 times and spend most of the festival at the jazz tent, where other acts for the day included trumpeter and singer Wendell Brunious and singer-pianist Tim Laughlin.

Brunious brought couples to their feet as he sang "I Will Never Be the Same" and "Big Chief," an upbeat number commonly performed at Mardi Gras that had many in the crowd dancing and hoisting umbrellas in the tradition known as second line. He closed his set with the New Orleans favorite "When the Saints Go Marching In."

On one of the bigger stages, the brass band Bonerama jammed before a crowd of thousands under sunny skies and a gentle breeze that broke through the warm temperatures.

"The sky is smiling upon us," said Quint Davis, the festival's producer. "We do it rain or shine, but we reach the spirit and zenith when in the sunshine."

Davis said Friday's opening day saw bigger crowds than last year.

That trend seemed to continue Saturday as thousands packed the grass spaces in front of the festival's largest stage to hear the day's final performer, Joel, who opened his set with "Movin' Out." He told the crowd that New York hurt with New Orleans when Hurricane Katrina hit in 2005. "After Hurricane Sandy, we're taking inspiration from you guys," he said as the crowd cheered in response.

He also did his classics, "Only the Good Die Young" and "Piano Man."

On a nearby stage, neo-soul singer Jill Scott dazzled fans, singing several of her hits including "It's Love," ''The Way," ''So In Love," and "Quick."

New Orleans native Darnie Williams described herself as Scott's No. 1 fan.

"She's just awesome," she said of Scott in between dancing and singing along with her. "She's just a true soul sister. She's real and her music is so soulful, much like Aretha and Gladys Knight."

Jazz Fest continues through Sunday and then resumes May 2-5. Festival-goers will be treated to traditional jazz, rock 'n roll, Cajun, gospel, blues, hip-hop, funk and zydeco.

Second-weekend headliners include Hall and Oates, Fleetwood Mac, Little Big Town, Aaron Neville and Troy "Trombone Shorty" Andrews.

___

Associated Press writer Stacey Plaisance in New Orleans contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-04-27-Music-Jazz%20Fest/id-953b6e61009a4364b2574b345b34516b

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Saturday, April 27, 2013

Who Needs a Gun? (Powerlineblog)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/301910587?client_source=feed&format=rss

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The School of Internet Marketing ? Spreaker Podcasting ... - GeekCast

Post image for The School of Internet Marketing ? Spreaker Podcasting & Broadcasting

by James Martell on April 26, 2013

James Martell, founder of The School of Internet Marketing, has been podcasting since before the word ?podcast? was ever even coined ? and a lot has changed in the last 10 years. Podcasting is now easier than ever before.

In this episode of The School of Internet Marketing podcast, James chats with Ivan Ho, fellow podcaster of the OMT Wired Up show, about the Spreaker platform. Spreaker makes it easy to publish your own podcast with little technological know-how.

You can use Spreaker to easily upload a recorded podcast or even broadcast live. In this episode of The School of Internet Marketing podcast, you?ll hear about the process of getting organized and prepared for publishing a well put-together podcast. The pair talks about:

  • Coming up with topics.
  • Professional touches to add to your podcast ? graphics, intros and more.
  • Getting organized for a show that flows well.
  • The ups and downs of doing business online.

Podcasting is a fantastic way to build an audience online ? and in order to be successful, it?s crucial to always be working on increasing your audience. Don?t assume podcasting isn?t right for your business ? as James talks about, it can actually be a great way to expand your reach and can fit a number of businesses with the right angle.

Listen in to learn about how podcasting is changing the game for many internet marketers and how you can use this platform to your advantage.

Visit:
http://www.theschoolofinternetmarketing.com

Source: http://geekcast.fm/archives/spreaker-podcasting-broadcasting/

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Federally funded research & development centers employed more than 3,000 postdoctoral researchers

Federally funded research & development centers employed more than 3,000 postdoctoral researchers [ Back to EurekAlert! ] Public release date: 26-Apr-2013
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Contact: Deborah Wing
dwing@nsf.gov
703-292-5344
National Science Foundation

According to a recent report released by the National Science Foundation, 22 of the nation's 39 federally funded research and development centers (FFRDCs) employed 3,011 postdocs in 2010, the year the latest data are available.

Three out of every four postdocs employed in the FFRDCs in 2010 were men. Foreign nationals on temporary visas made up 60 percent of all postdocs employed in FFRDCs. Men constituted a higher percentage of foreign nationals than of U.S. citizens and permanent residents--78 percent versus 72 percent.

Among U.S. citizens and permanent residents, 75 percent were reported to be white and 14 percent were reported to be Asian. The remainder were Hispanic at 4 percent, black or African American at 1 percent, and other races or of unknown race or ethnicity were reported at 5 percent.

Overall, 75 percent of all postdocs employed in FFRDCs were working in a science field, and another 23 percent were working in an engineering field. The most frequently reported science fields were physics and astronomy at 31 percent; followed by chemistry at 18 percent; biological sciences at 8 percent; and earth, atmospheric and ocean sciences at 8 percent.

FFRDCs received approximately $16.8 billion dollars in federal expenditures in fiscal year 2010. Included in this amount is more than $1 billion in federal expenditures from the American Recovery and Reinvestment Act of 2009. In addition to scientific research and analysis, many of the FFRCDs provide training opportunities for the country's aspiring researchers and scientists through postdoctoral appointments.

###

For more information on this report, please contact Dan Foley.

Please visit the NSF's National Center for Science and Engineering Statistics for more reports and other products.

-NSF-


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Federally funded research & development centers employed more than 3,000 postdoctoral researchers [ Back to EurekAlert! ] Public release date: 26-Apr-2013
[ | E-mail | Share Share ]

Contact: Deborah Wing
dwing@nsf.gov
703-292-5344
National Science Foundation

According to a recent report released by the National Science Foundation, 22 of the nation's 39 federally funded research and development centers (FFRDCs) employed 3,011 postdocs in 2010, the year the latest data are available.

Three out of every four postdocs employed in the FFRDCs in 2010 were men. Foreign nationals on temporary visas made up 60 percent of all postdocs employed in FFRDCs. Men constituted a higher percentage of foreign nationals than of U.S. citizens and permanent residents--78 percent versus 72 percent.

Among U.S. citizens and permanent residents, 75 percent were reported to be white and 14 percent were reported to be Asian. The remainder were Hispanic at 4 percent, black or African American at 1 percent, and other races or of unknown race or ethnicity were reported at 5 percent.

Overall, 75 percent of all postdocs employed in FFRDCs were working in a science field, and another 23 percent were working in an engineering field. The most frequently reported science fields were physics and astronomy at 31 percent; followed by chemistry at 18 percent; biological sciences at 8 percent; and earth, atmospheric and ocean sciences at 8 percent.

FFRDCs received approximately $16.8 billion dollars in federal expenditures in fiscal year 2010. Included in this amount is more than $1 billion in federal expenditures from the American Recovery and Reinvestment Act of 2009. In addition to scientific research and analysis, many of the FFRCDs provide training opportunities for the country's aspiring researchers and scientists through postdoctoral appointments.

###

For more information on this report, please contact Dan Foley.

Please visit the NSF's National Center for Science and Engineering Statistics for more reports and other products.

-NSF-


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?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/nsf-ffr042613.php

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Travel Startup AnyRoad Tries To Provide Anything But Your Typical Travel Tour

anyroad-tokyoTwo years ago, I had a terrible experience at the Great Wall when I visited its most popular corridor in Badaling. Trapped between tens of thousands of local tourists for miles upon miles one scorchingly humid August day, I eventually managed to get off by riding a roller coaster down the Great Wall that ended up in a bear park. Really! I’m not alone. AnyRoad co-founders Daniel and Jonathan Yaffe almost ended up doing the same thing, but they were smarter. They asked around and found out about remote parts of the wall where you could walk for miles without seeing another soul. It took hours to get there, but they got lucky and met a courteous taxi driver who showed them exactly what they wanted — that endless, breathtaking view of the crumbling Wall stretching for hundreds of miles into the distance. With that as inspiration, they decided to do a startup together that would offer custom tours to people in cities like Tokyo, Rio de Janeiro, Jerusalem, San Francisco and more. The Yaffe brothers have a colorful background. The older one, Jonathan, founded and was a principal of a charter school named KAIS International in Tokyo for several years, while the younger one, Daniel, ran and sold a drinking magazine called Drink Me and is releasing a book on whiskey later this year. Their technical co-founder Michalis Polakis is a former Soundcloud engineer. They say they’re not quite like YC-backed Vayable, or other marketplaces for experiences, because they’re partnering with established tour guides and small companies instead of regular, everyday locals that want to give people experiences in their spare time. AnyRoad has 200 tours available through 150 guides so far in five countries. The average ticket price being about $180. These include experiences like a Candomble tour in Rio de Janeiro, which teaches people about the history of the dance and music or a visit to a whiskey distillery in Brooklyn. About 80 percent of the company’s booking are from outside the U.S. In their two month beta, they said that bookings are tripling each month and more than 1 percent of visitors to the site book a tour. AnyRoad takes a 14 percent commission off each one. They had to meet with more than 3,000 tour guides throughout different countries over 18 months to figure out different pain points in the booking process. The challenges are,

Source: http://feedproxy.google.com/~r/Techcrunch/~3/-3q9ilK4GU4/

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Friday, April 26, 2013

SecondMarket Confirms Layoffs To Have Leaner Cost Structure, Become ?Break-Even?

SecondMarketSecondMarket’s CEO Barry Silbert just confirmed that the company had layoffs this morning. From a tipster, we had heard it was as much as one-third of the company’s headcount but SecondMarket says it was less than that. The rationale? Basically, Silbert said that the company had grown a “bloated cost structure,” from when it had a model that was based on transaction fees. SecondMarket offers liquidity to privately-held companies by letting shareholders sell equity in a manner that’s largely controlled by the companies and compliant with SEC rules. He called the decision “gut wrenching” and “stressful,” but said that the move would enable the company to have $25 million in cash in the bank and function on a break-even basis. It’s not the first time the company has had layoffs. They had to let go about 10 percent of staff last year in the wake of the Facebook IPO. The social network had made up a meaningful number of private stock transactions on the platform and when it went out to the public market, the company couldn’t justify certain positions. In spite of the loss of Facebook, SecondMarket’s overall transaction volume even grew a little bit, buoyed by other growth-stage companies that have decided to hold off on IPOs and reward their long-time employees in other ways. The company seems to be diversifying a bit beyond privately-held tech companies as well. Earlier this week, they convinced a boutique bank named First Advantage to delist itself from public markets and join SecondMarket’s platform. Here’s Silbert’s statement and the company says it’s not commenting beyond this. SecondMarket Org Changes I admit it, I screwed up. While the transition of SecondMarket from a telephone broker of illiquid assets in 2005 to the technology-driven reinvented stock market that we are today has been quite successful, I have done a poor job managing our cost structure during this transition. As a result, there are a number of high quality, hard-working SecondMarket family members who are now looking for their next challenge. So what went wrong? Reflecting on the past few years, the biggest mistake that I made was treating our cash in the bank and top line revenue as the ultimate gauge of the health of the company. The problem with that approach is that it helped obfuscate the bloated cost structure that we had in place from the period in our history when our

Source: http://feedproxy.google.com/~r/Techcrunch/~3/Gbhj0Fa-Pgg/

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Pushing the boundaries of transcription

Friday, April 26, 2013

Like musicians in an orchestra who have the same musical score but start and finish playing at different intervals, cells with the same genes start and finish transcribing them at different points in the genome. For the first time, researchers at EMBL have described the striking diversity of messenger RNAs (mRNAs) that such start and end variation produces, even from the simple genome of yeast cells. Their findings, published today in Nature, shed new light on the importance of mRNA boundaries in determining the functional potential of genes.

Hundreds of thousands of unique mRNA transcripts are generated from a genome of only about 8000 genes, even with the same genome sequence and environmental condition. "We knew that transcription could lead to a certain amount of diversity, but we were not expecting it to be so vast," explains Lars Steinmetz, who led the project. "Based on this diversity, we would expect that no yeast cell has the same set of messenger RNA molecules as its neighbour."

The traditional understanding of transcription was that mRNA boundaries were relatively fixed. While it has long been known that certain parts of mRNAs can be selectively 'spliced' out, this phenomenon is very rare in baker's yeast, meaning that the textbook one gene - one mRNA transcript relationship should hold. Recent studies have suggested that things aren't quite that simple, inspiring the EMBL scientists to create a new technique to capture both the start and end points of single mRNA molecules. They now discovered that each gene could be transcribed into dozens or even hundreds of unique mRNA molecules, each with different boundaries.

This suggests that not only transcript abundance, but also transcript boundaries should be considered when assessing gene function. Altering the boundaries of mRNA molecules can affect how long they stay intact, cause them to produce different proteins, or direct them or their protein products to different locations, which can have a profound biological impact. Diversifying mRNA transcript boundaries within a group of cells, therefore, could equip them to adapt to different external challenges.

The researchers expect that such an extent of boundary variation will also be found in more complex organisms, including humans, where some examples are already known to affect key biological functions. The technology to measure these variations across the entire genome as well as a catalogue of boundaries in a well-studied organism are a good starting point for further research. "Now that we are aware of how much diversity there is, we can start to figure out what factors control it," points out Vicent Pelechano, who performed the study with Wu Wei. Wei adds: "Our technique also exposed new mRNAs that other techniques could not distinguish. It will be exciting to investigate how these and general variation in transcript boundaries actually extend the functional capacity of a genome."

###

European Molecular Biology Laboratory: http://www.embl.org

Thanks to European Molecular Biology Laboratory for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127960/Pushing_the_boundaries_of_transcription

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Melissa Gilbert and Timothy Busfield Tie the Knot!

The two TV stars are hitched! See more stars who made their romances official.

Source: http://www.ivillage.com/celebrity-weddings-0/1-b-16623?dst=iv%3AiVillage%3Acelebrity-weddings-0-16623

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Tuesday, April 23, 2013

The bee's knees for detecting disease

The bee's knees for detecting disease [ Back to EurekAlert! ] Public release date: 22-Apr-2013
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Contact: Florian Aigner
florian.aigner@tuwien.ac.at
43-158-801-41027
Vienna University of Technology

Fire blight is a serious threat to fruit trees. Now a quick test has been developed at the Vienna University of Technology, which can indicate the danger early -- with the help of bees

This press release is available in German.

When blossoms and leaves wilt and turn black, it is usually too late: the plant disease fire blight damages especially apple trees and pear trees, clearing the affected trees is often the only chance left. Within a single season, fire blight can destroy an entire orchard. However, researchers at the Vienna University of Technology together with the Austrian Agency for Health and Food Safety (AGES) have now developed a method to detect the disease very quickly. Bees visit many trees at the same time and so they bring the dangerous bacteria back to the hive, where a test station is located. A genetic test, tailor-made to detect fire blight DNA, then reveals if an imminent fire blight danger actually exists.

Bees as organic-sample collectors

Up till now, constantly monitoring a large orchard for fire blight has been practically impossible. This always involved manually collecting blossoms from all the trees and then examining them for the fire blight bacteria; and even then it could not be excluded that an affected branch had been overlooked. However, this arduous work can now be outsourced - to bee colonies that are already active around the blossoms anyway.

"Nowadays, bees are specifically located in many orchards to ensure adequate pollination," explains Heidi Halbwirth from the Institute of Chemical Engineering, Environmental Technology and Technical Biosciences of the Technical University of Vienna. The fire blight bacteria stick to the bees, they take the bacteria back to the hive, contributing to the spread of the disease. "Back at the hive, we attach small tubes lined with foil at the hive entrance, through which every bee must crawl", says Halbwirth. "If the bees have come into contact with the bacteria, then some bacteria are left behind on the foil linings." This bee monitoring method was developed in cooperation with the Austrian Agency for Health and Food Safety (AGES).

Quick test specifically for fire blight DNA

Already after just a few hours, the films may be removed and any bacteria present can be washed off. The washing solution is then subjected to a specially developed colour test, called the Blue EaLAMP, which examines for possible fire blight bacteria. "The liquid of the Blue LAMP reacts very specifically to the presence of the fire blight bacteria DNA," says Christian Gosch, who developed this test together with Heidi Halbwirth, Karl Stich and Thilo Fischer: At a temperature of 63C, the DNA is replicated on a massive scale by a biochemical chain reaction, and if any fire blight DNA is present the liquid will change its colour from purple to blue. The method is extremely sensitive and a presence of just 20 bacteria is sufficient to be detected.

Up till now, one had to collect blossoms and send them off to a laboratory for testing. However, with this new test fruit growers and beekeepers alike can determine for themselves within just a few hours whether there is actually fire blight in the locality. Previously, as a preventive measure, antibiotics such as streptomycin were often sprayed in the orchards whenever a high fire blight risk was just suspected on the basis of the season and weather conditions. This quick test should now provide reliable information as to whether such measures are necessary at all, or whether the area is currently free of fire blight. The flight range of bees is up to three kilometres and that is large enough to enable the monitoring of ones own orchard and the surrounding areas which provide a direct threat.

This quick test of the TU Vienna has already been patented and it is to be noted that it is not the first patent that has emerged from the research performed by Heidi Halbwirth, Christian Gosch, Thilo C. Fischer and Karl Stich. In recent years, they already developed environmentally friendly fire blight control agents that can be used instead of antibiotics.

###

Further information:

PD Dr. Heidi Halbwirth
Institute of Chemical Engineering
Vienna University of Technology
Getreidemarkt 9, 1060 Wien
+43-1-58801-166559
heidi.halbwirth@tuwien.ac.at

Dr. Christian Gosch
Institute of Chemical Engineering
Vienna University of Technology
Getreidemarkt 9, 1060 Wien
+43-1-58801-166654
christian.gosch@tuwien.ac.at

Ao Univ.Prof. Dr. Karl Stich
Institute of Chemical Engineering
Vienna University of Technology
Getreidemarkt 9, 1060 Wien
+43-1-58801-166503
karl.stich@tuwien.ac.at


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?


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The bee's knees for detecting disease [ Back to EurekAlert! ] Public release date: 22-Apr-2013
[ | E-mail | Share Share ]

Contact: Florian Aigner
florian.aigner@tuwien.ac.at
43-158-801-41027
Vienna University of Technology

Fire blight is a serious threat to fruit trees. Now a quick test has been developed at the Vienna University of Technology, which can indicate the danger early -- with the help of bees

This press release is available in German.

When blossoms and leaves wilt and turn black, it is usually too late: the plant disease fire blight damages especially apple trees and pear trees, clearing the affected trees is often the only chance left. Within a single season, fire blight can destroy an entire orchard. However, researchers at the Vienna University of Technology together with the Austrian Agency for Health and Food Safety (AGES) have now developed a method to detect the disease very quickly. Bees visit many trees at the same time and so they bring the dangerous bacteria back to the hive, where a test station is located. A genetic test, tailor-made to detect fire blight DNA, then reveals if an imminent fire blight danger actually exists.

Bees as organic-sample collectors

Up till now, constantly monitoring a large orchard for fire blight has been practically impossible. This always involved manually collecting blossoms from all the trees and then examining them for the fire blight bacteria; and even then it could not be excluded that an affected branch had been overlooked. However, this arduous work can now be outsourced - to bee colonies that are already active around the blossoms anyway.

"Nowadays, bees are specifically located in many orchards to ensure adequate pollination," explains Heidi Halbwirth from the Institute of Chemical Engineering, Environmental Technology and Technical Biosciences of the Technical University of Vienna. The fire blight bacteria stick to the bees, they take the bacteria back to the hive, contributing to the spread of the disease. "Back at the hive, we attach small tubes lined with foil at the hive entrance, through which every bee must crawl", says Halbwirth. "If the bees have come into contact with the bacteria, then some bacteria are left behind on the foil linings." This bee monitoring method was developed in cooperation with the Austrian Agency for Health and Food Safety (AGES).

Quick test specifically for fire blight DNA

Already after just a few hours, the films may be removed and any bacteria present can be washed off. The washing solution is then subjected to a specially developed colour test, called the Blue EaLAMP, which examines for possible fire blight bacteria. "The liquid of the Blue LAMP reacts very specifically to the presence of the fire blight bacteria DNA," says Christian Gosch, who developed this test together with Heidi Halbwirth, Karl Stich and Thilo Fischer: At a temperature of 63C, the DNA is replicated on a massive scale by a biochemical chain reaction, and if any fire blight DNA is present the liquid will change its colour from purple to blue. The method is extremely sensitive and a presence of just 20 bacteria is sufficient to be detected.

Up till now, one had to collect blossoms and send them off to a laboratory for testing. However, with this new test fruit growers and beekeepers alike can determine for themselves within just a few hours whether there is actually fire blight in the locality. Previously, as a preventive measure, antibiotics such as streptomycin were often sprayed in the orchards whenever a high fire blight risk was just suspected on the basis of the season and weather conditions. This quick test should now provide reliable information as to whether such measures are necessary at all, or whether the area is currently free of fire blight. The flight range of bees is up to three kilometres and that is large enough to enable the monitoring of ones own orchard and the surrounding areas which provide a direct threat.

This quick test of the TU Vienna has already been patented and it is to be noted that it is not the first patent that has emerged from the research performed by Heidi Halbwirth, Christian Gosch, Thilo C. Fischer and Karl Stich. In recent years, they already developed environmentally friendly fire blight control agents that can be used instead of antibiotics.

###

Further information:

PD Dr. Heidi Halbwirth
Institute of Chemical Engineering
Vienna University of Technology
Getreidemarkt 9, 1060 Wien
+43-1-58801-166559
heidi.halbwirth@tuwien.ac.at

Dr. Christian Gosch
Institute of Chemical Engineering
Vienna University of Technology
Getreidemarkt 9, 1060 Wien
+43-1-58801-166654
christian.gosch@tuwien.ac.at

Ao Univ.Prof. Dr. Karl Stich
Institute of Chemical Engineering
Vienna University of Technology
Getreidemarkt 9, 1060 Wien
+43-1-58801-166503
karl.stich@tuwien.ac.at


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/vuot-tbk042213.php

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Friday, April 19, 2013

Details emerge about suspects

[Updated at 3:51 p.m. ET]

BOSTON?Thousands of law enforcement officers are entering the 15th hour of a massive, door-to-door manhunt for a suspect in Monday's Boston Marathon bombings that wounded more than 170 people and left three dead.

A late-night police chase and shootout left one marathon bombing suspect?26-year-old Tamerlan Tsarnaev?dead and the other, his younger brother, on the run, police here said. One police officer was killed and another seriously wounded during the violent spree. The city of Boston and its surrounding areas have ground to a standstill as the manhunt continues in a 20-block radius of Watertown, with local leaders warning residents to stay indoors. Police also announced there will be a "controlled explosion" in a building in Cambridge on Friday afternoon.

"It is important that folks remain indoors, keep the doors locked and not open the door unless there is a uniformed law enforcement officer on the other side of it," Gov Deval Patrick said at a 12:30 p.m. press conference.

The suspect on the lam is Dzhokhar A. Tsarnaev, 19, of Cambridge, Mass., a student at the University of Massachusetts Dartmouth. He and his brother's family is originally from Chechnya, a volatile and once war-torn southern Russian republic. The family fled to Kyrgyzstan and eventually immigrated to the United States as refugees about 10 years ago.

His older brother studied at a local community college and was a Golden Gloves boxer. Tamerlan Tsarnaev also reportedly had a wife and young child. Dzhokhar Tsarnaev, who was remembered by former classmates as bright and personable, posted links to pro-Chechnyan independence sites on his social media page, and listed his world view as "Islam." It's unclear if either the separatist politics of Chechnya or their religion had anything to do with the suspects' crime. Tsarnaev appeared to be posting to his Twitter account even after the attacks, writing in his last post on Wednesday, "I'm a stress free kind of guy." His posts covered everything from cute photos of his cat to rap lyrics.

The suspects' uncle told the local CBS News station that the pair had lived in the country since 2002. The uncle, when told that one of his nephews was killed, replied that he deserved it. ?He deserved his. He absolutely deserved his,? Ruslan Tsarni said. ?They do not deserve to live

Marathon bombing suspect Tsarnaev (FBI)on this earth.?

In an emotional press conference, Tsarni said his nephews had brought shame upon his family, and called them "losers." He said they were not "able to settle themselves" and were "angry at everyone who was able to." He said he did not believe they were motivated by the radical politics in Chechnya or their Muslim religion.

"Dzhokhar, If you're alive, turn yourself in and ask for forgiveness from the victims [and] the injured," he said. "He put a shame on our family. He put a shame on the entire Chechnyan ethnicity. Turn yourself in."

He added that he hadn't been in touch with the family for several years but would not say why.

"I'm ready to kneel in front of them and ask their forgiveness," Tsarni said of the victims of his nephews' crime. "I respect this country; I love this country ... this country that gives everybody chance to be treated like human being."

The Wall Street Journal, citing unnamed law enforcement sources, said that one or both of the brothers traveled back to the Caucasus region of Russia for a year or more before returning to America again.

Tsarnaev's father, reached by the AP in Russia by phone, said his son was a "true angel" and wonderful student. He later told ABC's "Good Morning America" that he wanted his son to surrender peacefully.

The University of Massachusetts at Dartmouth announced shortly after 10:30 a.m. on Friday that they were evacuating the entire campus after learning Tsarnaev is a registered student there.

Earlier, at sunrise, Gov. Patrick ordered a shutdown of all public transit and for residents in the city of Boston and on its edges to stay indoors as a massive manhunt for the second suspect was underway. The Boston Globe reported that police are focusing on a 20-block area of Watertown and fear the suspect may be wearing explosives. Amtrak has also shut down all trains between Boston and New York.

?This situation is grave and we are trying to protect the public safety,? said Massachusetts State Police Col. Timothy Alben, who ordered a lockdown of Watertown, Waltham, Belmont, Cambridge, Newton, Allston and Brighton. Brookline was later ordered to be on lockdown as well. A no-fly zone has been declared over Watertown. The city of Boston was eerily quiet during Friday's rush hour, the city's busy intersections totally abandoned.

The mayhem began at approximately 10:20 p.m. Thursday when police said the bombing suspects shot and killed an MIT campus officer, Sean Collier, 26. The terror suspects then carjacked a Mercedes-Benz SUV with the driver inside and fled, eventually letting the driver go.

(Shortly before 2 a.m. Friday, MIT issued a statement on its website saying that the suspect "in this evening's shooting is no longer on campus. It is now safe to resume normal activities. Please remain vigilant in the coming hours." MIT, Harvard, Boston University and other local colleges have canceled classes.)

The suspects were then spotted in Watertown, where federal agents swarmed in. At approximately 3:30 a.m., Massachusetts State

Slain MIT police officer Sean Collier. (Middlesex DA)

Police issued a plea on Twitter for residents of Watertown to lock their doors and not open them for anyone, as dozens of police officers, many of them off duty, searched backyards and exteriors of houses there, and a police perimeter of several blocks was established.

Worried residents were also told to turn off their cell phones out of fear that they could trigger improvised explosive devices.

The suspects exchanged dozens of rounds of gunfire with patrol officers. According to the Washington Post, they also lobbed improvised explosive devices (IEDs) at officers.

Tamerlan Tsarnaev was shot by police and brought to Beth Israel Medical Center. He arrived at the hospital under cardiac arrest with multiple gunshot wounds and blast-like injuries to his chest. The second suspect fled, leading to the tense manhunt that is still underway at this hour.

A transit police officer, Richard H. Donohue, was seriously wounded during the exchange of gunfire, officials said.

K9 units and SWAT teams searched homes on Spruce Street as officers with a police robot searched an SUV that the suspects had abandoned. Multiple devices were left in the road and two handguns were recovered, according to police scanners.

"We believe this to be a terrorist," said Boston Police Commissioner Ed Davis, of Tsarnaev. "We believe this to be a man who has come here to kill people. We need to get him into custody."

[Related: FBI releases photos of suspects in Boston Marathon bombings]

In a radio alert issued issued to fellow officers, the suspect was described as a "white male with dark complexion ... with thick curly hair wearing a charcoal gray hooded sweatshirt ... possibly with an assault rifle and explosives."

Police in Watertown, Newton, Brighton and Cambridge were put on high alert. "Units use caution," an officer said. "He might have an explosive object on his person."

"Suspect 2" seen in 7-Eleven surveillance footage; police in Watertown (BPD/Getty)

President Barack Obama, who attended an interfaith service for the bombing victims in Boston on Thursday, was briefed on the overnight developments, the White House said early Friday. He received an updated briefing later in the day.

Police were able to track down images of the suspects after a victim of the attacks, Jeff Bauman, came to them with a description, Bloomberg reported Thursday. Bauman's legs were torn apart by the bomb.

--Yahoo News reporter Dylan Stableford contributed to this report from Connecticut. Liz Goodwin is reporting from New York.

Source: http://news.yahoo.com/blogs/lookout/boston-mit-shooting-explosion-suspect-watertown-064355149.html

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The Sale You've Been Asking For ? Bud's Warehouse

Well? we finally caved? after months and months of people asking for it, we?re finally going to do it?

From this Thursday, April 18th through next Wednesday, April 24th, you can get 25% OFF ANY UNFINISHED CABINET DOORS!

And that?s just part of our month-long Spring Cleaning Sale: You can still get 15% off any pre-owned cabinets AND all of our stained cabinet doors are only $5 each.

Just remember that all of the proceeds from Bud?s Warehouse go towards running our job training program. So you?re not only getting great products at a great price, you?re also helping out a great cause! For more information about our job training program or to donate tax deductible building supplies, call (303) 296-3990.

Bud?s Warehouse is open Monday though Friday from 10 a.m. to 5 p.m and 9 a.m. to 5 p.m. on Saturday.

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Source: http://budswarehouse.org/2013/04/18/the-sale-youve-been-asking-for/

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Israeli visit another sign of thaw with Turkey

By Parisa Hafezi

ANKARA (Reuters) - An Israeli delegation will visit Turkey for the first time in three years next week in another sign of thawing relations since the United States brokered a breakthrough in March, but any further advancement in ties was expected to be incremental.

Israel apologized to Turkey over the killing of nine Turks in a 2010 naval raid on a Gaza-bound flotilla and the two agreed to normalize relations in phone calls arranged by U.S. President Barack Obama on his recent trip to Israel.

Brokering a rapprochement could bolster U.S. influence in the Middle East, help ease Israel's diplomatic isolation as it confronts the challenge of Iran's nuclear program and improve regional coordination over Syria's two-year-old civil war.

But for all the diplomatic flurry, there were no illusions on either side that the relationship would be patched up as fully as Washington might hope, at least not any time soon.

"The honeymoon period between Israel and Turkey is over," said Ufuk Ulutas from the Ankara-based Foundation for Political, Economic and Social Research (SETA), a thinktank close to the Turkish government.

"Even if Israel takes other steps beside the apology, the two countries will not return to the heyday of the 1990s."

Monday's visit by the Israeli delegation, led by an adviser to Prime Minister Benjamin Netanyahu, will focus on the question of compensation to the families of those killed by Israeli marines aboard the Mavi Marmara three years ago.

But that was always going to be the easy part.

Ankara set precise conditions for re-installing ambassadors and fully normalizing ties: an apology, compensation and Israel lifting its embargo on the Gaza strip.

"We had three conditions and our view has not changed. Talk of Turkey ignoring the other two conditions after the apology is nothing but rumor and not a reflection of our position," an official close to Turkish Prime Minister Tayyip Erdogan said.

That leaves a resumption in ties hostage to Israeli policy towards the Palestinian enclave.

Israel has made clear it did not commit to ending its Gaza blockade as part of the reconciliation, saying days after the apology that it could clamp down even harder on the enclave if security is threatened.

PLAYING TO THE GALLERY

The reconciliation may have fallen well short of the end to the Gaza blockade which Erdogan had routinely insisted on, but mindful of elections next year in which he hopes to run for an empowered presidency, his ruling AK Party has nonetheless presented the episode as a decisive diplomatic victory.

Billboards thanking Erdogan for securing the apology sprang up around the capital Ankara within hours. Turkish media praised the prime minister for his "principled diplomacy" and the "diplomatic coup" that led to the Israeli "surrender".

"The AK Party is focusing on the apology for domestic policy use and trying to ignore other parts of the deal," said Cagri Erhan, a political science lecturer at Ankara University.

"The lifting of the blockade seems very unlikely and some families of victims are not ready to drop the legal case even if the compensation is paid," he said.

Survivors of the Mavi Marmara incident said this month the apology did not go far enough and vowed to pursue Israeli soldiers in court.

But so strong is the U.S. interest in a rapprochement - Secretary of State John Kerry described it as vital to regional stability - that there could be a resumption in intelligence sharing on issues including Syria and Iran behind the scenes.

With so many common concerns, both Turkey and Israel are eager to keep their relationships with Washington strong.

"There are huge interests here. The United States is a major player in this and it wants its allies to cooperate with it on first and foremost on Iran ... and Syria," senior Israeli defense official Amos Gilad told Israel Radio last month.

The prospect of a rapprochement has also piqued the interest of energy investors, who see potential for a radical change in the geopolitics of the eastern Mediterranean, allowing newly-discovered Israeli gas to be pumped to energy-hungry Turkey and on to other markets, undermining Russia's supply dominance.

"Everything depends on our ties with Israel," said a senior Turkish official, asking not to be named. "We can consider such a proposal if ties are restored. But until then, all such deals have to wait."

(Additional reporting by Orhan Coskun, Gulsen Solaker in Ankara and Dan Williams in Jerusalem; Editing by Nick Tattersall and Sonya Hepinstall)

Source: http://news.yahoo.com/israeli-visit-another-sign-thaw-turkey-165230413.html

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Tech Stocks: Apple, eBay, Facebook lead tech retreat

By Benjamin Pimentel, MarketWatch

SAN FRANCISCO (MarketWatch) ? Technology stocks retreated Thursday, as shares of eBay Inc. dropped sharply a day after the online auction site posted a disappointing forecast.

Shares of Google Inc. /quotes/zigman/93888/quotes/nls/goog GOOG -2.13% , Microsoft Corp. /quotes/zigman/20493/quotes/nls/msft MSFT -0.12% ?and IBM Corp. /quotes/zigman/230066/quotes/nls/ibm IBM -1.20% ?also fell as the three tech giants geared up for their quarterly reports due after the close.

But it was eBay /quotes/zigman/76117/quotes/nls/ebay EBAY -5.85% ?that was in the spotlight as the stock fell more than 5% after the company reported higher first-quarter profit, but posted a weaker-than-expected forecast.

Google among stocks to watch

Michael Casey details three key stocks, including Google and IBM, to watch on Thursday.

The stock was downgraded to neutral from outperform by Macquarie Equities Research analyst Ben Schachter who said the company?s second-quarter outlook puts more pressure on eBay to meet its full-year forecasts.

Shares of Apple Inc. /quotes/zigman/68270/quotes/nls/aapl AAPL -2.67% slipped about 3% to $391.65, a day after dropping below the $400 mark for the first time since December 2011.

Two brokers cut their price targets for Apple ahead of the company?s fiscal second quarter report next week.

BMO Capital cut its price target to $460 from $580, saying the company ?faces a choice between pursuing growth vs. preserving margins.?

Janney Capital cut its ?fair value? target to $520 from $610, citing its belief that Apple?s ?near-term valuation multiple will likely remain pressured with continued downward earnings revisions, maturing smartphone product category, and limited visibility on new product innovation.? Both brokers continue to rate the stock as a buy.

Apple posted some gains early in the session on news that Verizon Communications /quotes/zigman/262341/quotes/nls/vz VZ +2.77% activated 4 million iPhones in the first quarter. Verizon, which reported a 16% gain in profit, saw its shares rise more than 3%.

Facebook /quotes/zigman/9962609/quotes/nls/fb FB -3.51% shares also sank 4% to $25.46, leading other social media stocks into the red. LinkedIn /quotes/zigman/5131883/quotes/nls/lnkd LNKD -3.42% also was down 4%, while Zynga /quotes/zigman/7720406/quotes/nls/znga ZNGA -1.24% was off 5% and Groupon /quotes/zigman/7720406/quotes/nls/znga ZNGA -1.24% gave up 4%.

On the upside, shares of Overstock.com /quotes/zigman/87370/quotes/nls/ostk OSTK +37.00% soared 33% after the company reported results, highlighted by a 19% gain in revenue.

The Nasdaq Composite Index /quotes/zigman/12633936 COMP -1.20% gave up 43 points, or 1.3%, to stand at 3,162. The Philadelphia Semiconductor Index /quotes/zigman/1468249 SOX -0.90% was down 1%, while the Morgan Stanley High Tech 35 Index /quotes/zigman/6015481 MSH -1.72% gave up 2%.

/quotes/zigman/93888/quotes/nls/goog

US : U.S.: Nasdaq

Volume: 2.56M

April 18, 2013 4:00p

Market Cap

$259.14 billion

Rev. per Employee

$927,536

/quotes/zigman/20493/quotes/nls/msft

US : U.S.: Nasdaq

Volume: 53.48M

April 18, 2013 4:00p

Market Cap

$241.45 billion

Rev. per Employee

$774,085

/quotes/zigman/230066/quotes/nls/ibm

US : U.S.: NYSE

Volume: 4.80M

April 18, 2013 4:01p

Market Cap

$233.68 billion

Rev. per Employee

$240,663

/quotes/zigman/76117/quotes/nls/ebay

US : U.S.: Nasdaq

Volume: 24.96M

April 18, 2013 4:00p

Rev. per Employee

$460,667

/quotes/zigman/68270/quotes/nls/aapl

US : U.S.: Nasdaq

Volume: 23.57M

April 18, 2013 4:00p

Market Cap

$378.25 billion

/quotes/zigman/262341/quotes/nls/vz

US : U.S.: NYSE

Volume: 17.95M

April 18, 2013 4:02p

Market Cap

$141.60 billion

Rev. per Employee

$631,658

/quotes/zigman/9962609/quotes/nls/fb

US : U.S.: Nasdaq

Volume: 38.86M

April 18, 2013 4:00p

/quotes/zigman/5131883/quotes/nls/lnkd

US : U.S.: NYSE

Volume: 1.98M

April 18, 2013 4:00p

Rev. per Employee

$281,177

/quotes/zigman/7720406/quotes/nls/znga

US : U.S.: Nasdaq

Volume: 28.04M

April 18, 2013 4:00p

Rev. per Employee

$418,989

/quotes/zigman/7720406/quotes/nls/znga

US : U.S.: Nasdaq

Volume: 28.04M

April 18, 2013 4:00p

Rev. per Employee

$418,989

/quotes/zigman/87370/quotes/nls/ostk

US : U.S.: Nasdaq

Volume: 1.60M

April 18, 2013 4:00p

Market Cap

$271.03 million

Rev. per Employee

$845,607

/quotes/zigman/12633936

US : U.S.: Nasdaq

Volume: 0.00

April 18, 2013 5:15p

/quotes/zigman/1468249

US : PHLX Ind Cur

Volume: 0.00

April 18, 2013 5:16p

/quotes/zigman/6015481

US : NYSE Glb Ind

Volume: 0.00

April 18, 2013 5:57p

Benjamin Pimentel is a MarketWatch reporter based in San Francisco. Follow him on Twitter @BenPimentel.

Source: http://feeds.marketwatch.com/~r/marketwatch/software/~3/tK0O1tqXw3Q/story.asp

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